Fantasy Football Week 10 Rankings: Latest Position-by-Position Rundown

Football: San Francisco 49ers Christian McCaffrey (23) in action, looks on vs. Los Angeles Rams at SoFi Stadium.
Inglewood, CA 10/30/2022
CREDIT: John W. McDonough (Photo by John W. McDonough/Sports Illustrated via Getty Images)
(Set Number: X164222 TK1) — Football: San Francisco 49ers Christian McCaffrey (23) in action, looks on vs. Los Angeles Rams at SoFi Stadium. Inglewood, CA 10/30/2022 CREDIT: John W. McDonough (Photo by John W. McDonough/Sports Illustrated via Getty Images) (Set Number: X164222 TK1)

Week 10 of the 2022 NFL season should be all kinds of fun.

Hopefully, it will be jam-packed with fantasy production, too.

The Seattle Seahawks and Tampa Bay Buccaneers are tussling in Germany. The Minnesota Vikings and Buffalo Bills are locking horns. The Dallas Cowboys and Green Bay Packers are going toe-to-toe. The Sunday slate closes with a doozy, as the San Francisco 49ers host the Los Angeles Chargers. If that wasn't enough, the Philadelphia Eagles put their undefeated record on the line Monday night against the Washington Commanders.

Even with four teams on a bye—including the Cincinnati Bengals and Baltimore Ravens—the paths to potential fantasy production are abundant. Let's map them out then with weekly rankings at the four offensive skill spots and a deeper dive into a top performer at each position.

Quarterback

CHICAGO, ILLINOIS - NOVEMBER 06: Tua Tagovailoa #1 of the Miami Dolphins looks on prior to the game against the Chicago Bears at Soldier Field on November 06, 2022 in Chicago, Illinois. (Photo by Michael Reaves/Getty Images)

Top 10

1. Josh Allen, BUF (vs. MIN)

2. Jalen Hurts, PHI (vs. WAS)

3. Patrick Mahomes, KC (vs. JAX)

4. Tua Tagovailoa, MIA (vs. CLE)

5. Justin Fields, CHI (vs. DET)

6. Kyler Murray, ARI (at LAR)

7. Justin Herbert, LAC (at SF)

8. Geno Smith, SEA (at TB)

9. Trevor Lawrence, JAX (at KC)

10. Tom Brady, TB (vs. SEA)

With first-year coach Mike McDaniel calling the shots in Miami and Tyreek Hill joining Jaylen Waddle to form the league's most explosive receiver duo, Tua Tagovailoa is positioned to be the best quarterback in fantasy any given week.

He's one of two signal-callers—along with the red-hot Justin Fields—to tally 50-plus fantasy points over the past two weeks, per FantasyPros. In each of those contests, Tagovailoa completed at least 70 percent of his passes while throwing for a combined 684 yards, six touchdowns and zero interceptions.

This is less of a hot streak than it is pure magic. It's possible the magic runs out at some point, but he keeps giving the fantasy world reasons to believe.

Running Back

KANSAS CITY, MO - NOVEMBER 06: Derrick Henry #22 of the Tennessee Titans runs the ball against the Kansas City Chiefs at GEHA Field at Arrowhead Stadium on November 6, 2022 in Kansas City, Missouri. (Photo by Cooper Neill/Getty Images)

Top 20

1. Saquon Barkley, NYG (vs. HOU)

2. Christian McCaffrey, SF (vs. LAC)

3. Alvin Kamara, NO (at PIT)

4. Derrick Henry, TEN (vs. DEN)

5. Austin Ekeler, LAC (at SF)

6. Nick Chubb, CLE (at MIA)

7. Ken Walker III, SEA (at TB)

8. Travis Etienne Jr., JAX (at KC)

9. Josh Jacobs, LV (vs. IND)

10. Dameon Pierce, HOU (at NYG)

11. Dalvin Cook, MIN (at BUF)

12. Jonathan Taylor, IND (at LV)

13. Miles Sanders, PHI (vs. WAS)

14. Aaron Jones, GB (vs. DAL)

15. Leonard Fournette, TB (vs. SEA)

16. David Montgomery, CHI (vs. DET)

17. D'Andre Swift, DET (at CHI)

18. Jeff Wilson Jr., MIA (vs. CLE)

19. Antonio Gibson, WAS (at PHI)

20. Tony Pollard, DAL (at GB)

Derrick Henry is once again proving that running backs can be fantasy-relevant without playing a major part in the passing game.

Well, that's true of running backs named Derrick Henry, at least.

His season started quietly, as he managed just 107 scrimmage yards and a score in his first two outings combined. In the six contests since, though, he's back to being football's best bulldozer. He has 763 rushing yards and eight rushing scores over this stretch, plus 14 receptions (on 17 targets) for another 140 yards.

Wide Receiver

SANTA CLARA, CALIFORNIA - OCTOBER 23: Deebo Samuel #19 of the San Francisco 49ers catches a pass in the fourth quarter against L'Jarius Sneed #38 of the Kansas City Chiefs at Levi's Stadium on October 23, 2022 in Santa Clara, California. (Photo by Thearon W. Henderson/Getty Images)

Top 20

1. Cooper Kupp, LAR (vs. ARI)

2. Tyreek Hill, MIA (vs. CLE)

3. Stefon Diggs, BUF (vs. MIN)

4. Justin Jefferson, MIN (at BUF)

5. A.J. Brown, PHI (vs. WAS)

6. Davante Adams, LV (vs. IND)

7. DeAndre Hopkins, ARI (at LAR)

8. Jaylen Waddle, MIA (vs. CLE)

9. Amon-Ra St. Brown, DET (at CHI)

10. CeeDee Lamb, DAL (at GB)

11. Deebo Samuel, SF (vs. LAC)

12. Amari Cooper, CLE (at MIA)

13. Mike Evans, TB (vs. SEA)

14. DK Metcalf, SEA (at TB)

15. Chris Olave, NO (at PIT)

16. JuJu Smith-Schuster, KC (vs. JAX)

17. Brandon Aiyuk, SF (vs. LAC)

18. Allen Lazard, GB (vs. DAL)

19. Christian Kirk, JAX (at KC)

20. DeVonta Smith, PHI (vs. WAS)

Last season, Deebo Samuel posted the 10th-most point-per-reception fantasy points of all players, per FantasyPros. This season, he's just 30th among receivers.

What happened? Well, he lost a game to injury, but the much bigger issue has been facing a lot of defenses that are game-planning to stop him. He's had a single 100-yard receiving effort and hasn't broken off a 10-yard run since Week 2.

Well, with Christian McCaffrey now on board and fully ingrained in the offense, defenses can't pay such close attention to Samuel, anymore. This 49ers offense should put opposing defenses into a string of pick-your-poison scenarios, and if that gets Samuel into more one-on-one matchups, his numbers could skyrocket in a hurry.

Tight End

LANDOVER, MD - NOVEMBER 06: T.J. Hockenson #87 of the Minnesota Vikings warms up before the game against the Washington Commanders at FedExField on November 6, 2022 in Landover, Maryland. (Photo by Scott Taetsch/Getty Images)

Top 10

1. Travis Kelce, KC (vs. JAX)

2. Dallas Goedert, PHI (vs. WAS)

3. T.J. Hockenson, MIN (at BUF)

4. George Kittle, SF (vs. LAC)

5. Zach Ertz, ARI (at LAR)

6. Gerald Everett, LAC (at SF)

7. Greg Dulcich, DEN (at TEN)

8. Pat Freiermuth, PIT (vs. NO)

9. Tyler Higbee, LAR (vs. ARI)

10. Robert Tonyan, GB (vs. DAL)

T.J. Hockenson isn't immune to a bad game, but that's true of every tight end not named Travis Kelce.

In the non-Kelce division, though, Hockenson keeps climbing closer to the top. His first game with the Vikings was everything fantasy managers could have wanted. Granted, he didn't find the end zone, but he did haul in all of nine of his targets for 70 yards.

Over his last five games, he's had one dud (one reception for six yards), one so-so effort (four catches, 48 yards) and three games with 70-plus receiving yards. If he's not an elite fantasy tight end already, he's loudly knocking on that door.